RESEARCH SCOPE This Ola HAWAII funding opportunity is open to the full spectrum of basic, clinical and behavioral biosciences research. Pre-proposals involving fundamental research seeking new knowledge about basic molecular mechanisms, using newly developed tools or repurposing existing tools, will...
The University of Hawaiʻi will receive more than $23 million from now through 2022 for a specialized center focused on advancing health for citizens who suffer disproportionately from genetic, environmental and socio-economic related disparities in health and healthcare access.
The goal of the center is contained in its name: “Ola HAWAIʻI.” Ola, which means health or to heal in the Native Hawaiian language, and HAWAIʻI, in this case an acronym standing for “Health And Wellness Achieved by Impacting Inequalities”.
With its piko (center) based at the John A. Burns School of Medicine (JABSOM), the research activity will spread throughout the University of Hawaiʻi at Mānoa (UHM) encompassing:
- The (UHM) College of Health Sciences and Social Welfare:
- The John A. Burns School of Medicine (JABSOM)
- The Myron B. Thompson School of Social Work (MBTSSW)
- The Department of Social Work, Office of Public Health Studies and Center on Aging
- The School of Nursing and Dental Hygiene (SONDH)
- And other UHM partners including:
- The UH Cancer Center (UHCC),
- The College of Natural Sciences (CNS)
- The Pacific Biosciences Research Center (PBRC)
“This is a broad-based academic endeavor and one that is strong because of the way it brings people together for common purpose even with differences in training and professional identity,” said Jerris Hedges, MD, Dean of JABSOM.
UH Mānoa and its partners earned this significant, multi-million dollar national investment by their strong records of commitment to educating and serving underrepresented populations facing health disparities. Dr. Hedges and MBTSSW Dean Dr. Noreen Mokuau lead the grant, funded by the National Institute on Minority Health and Health Disparities (NIMHD), part of the National Institutes of Health.
About health disparities in Hawai’i
“Overall, Hawaiʻi ranks as one of the healthiest states in the nation, yet health disparities continue to exist with deadly impact for many populations including Native Hawaiians, Pacific Islanders and Filipinos,” said Dr. Mokuau. “With support from the U.S. Congressional Delegation and University of Hawaiʻi leadership, a talented assembly of interdisciplinary researchers successfully shaped a plan of research action to address the most serious of health disparities in Hawaiʻi.”
The Ola HAWAIʻI Specialized Research Center will support multidisciplinary teams of investigators and community collaborators as they conduct basic biomedical, behavioral and clinical research on the causes of health disparities and the most effective solutions to reduce those disparities among the underserved, multiethnic populations in Hawaiʻi.
The center will harness the power of diverse thought to determine the most appropriate, effective interventions for health disparities. There are three specific aims:
- Bring together high-impact team-science research addressing health disparities
- Strengthen and diversify the basic biomedical, behavioral and clinical research workforce focusing on health disparities
- Enhance, consolidate and sustain core facilities and resources for health disparities research
UH Mānoa is one of only seven universities where these Specialized Research Centers are being funded. The others are located in Florida, Alabama, North Carolina, Tennessee, Arizona and Puerto Rico.
“Institutions with a historical commitment to diversity are essential to supporting scientific research and providing health care to underserved communities,” said NIMHD Director Dr. Eliseo J. Pérez-Stable. “These institutions are uniquely positioned to engage minority populations in research, and in the translation of research advances into culturally competent, measurable and sustained improvements in health outcomes.”
Proposed community-based “Pilot” research project include:
- Backyard Aquaponics: Promoting Healthy Eating among Native Hawaiian Families
- Exploring First Foods of Keiki on Oʻahu, Hawaiʻi
- Understanding resiliency and well-being among Native Hawaiian and Micronesian families who are exposed to the trauma and risk associated with being houseless
- Tenofovir disoproxil fumarate nanoparticles for local prevention of HIV infection
- Fatty Liver Disease in HIV infected Individuals
- Development of a platform for translational Affective Neuroscience: fMRI imaging of fear response in a mouse model of PTSD
In Hawaiʻi, the investigators whose research projects were selected for RCMI support as part of the Center, following a highly competitive process, are:
Lishomwa C. Ndhlovu, MD, PhD, a tenured JABSOM Associate Professor HIV immunologist (originally from Zambia), will serve as the contact Principal Investigator in a Multiple-Principal Investigator project on the role of macrophages in atherosclerosis in HIV-infected individuals, with JABSOM’s Dominic C. Chow, MD, PhD, an AIDS clinician scientist, and William A. Boisvert, PhD, a basic cardiovascular scientist, Department of Medicine.
Alika K. Maunakea, PhD, a Native Hawaiian tenure-track JABSOM Assistant Professor (Department of Native Hawaiian Health), will apply his considerable expertise in epigenetics to uncover immuno-epigenetic signatures which are predictive of diabetes mellitus outcomes by integrating detailed individual-level health behavior, clinical/immunologic, genetic, and monocyte- specific epigenomic data with neighborhood-level social environment data from the NCI-funded Multiethnic Cohort Study of Diet and Cancer.
Lucia Seale, PhD, a Latina junior investigator at JABSOM, Department of Cell and Molecular Biology, will test the hypothesis that selenocysteine lyase regulates glucose homeostasis through regulation of glycine metabolism and pyruvate levels via interaction with pyruvate carboxylase to fuel energy metabolism. This research will provide insights into obesity and diabetes.
Deborah Goebert, PhD, a community investigator, along with co-investigator Diane Eckert, MD, both from the JABSOM Department of Psychiatry, will use a community-engaged approach and cultural knowledge and practices to develop and demonstrate a culturally responsive, multi-faceted youth suicide prevention program that has a positive impact in a Native Hawaiian community.
Yan Yan Wu, PhD, of the MBTSSW Office of Public Health Studies, is expert in developing complex statistical tools to model the effects of genes and environmental factors associated with complex human diseases.
About the National Institute for Minority Health and Health Disparities:
NIMHD is one of NIH’s 27 Institutes and Centers. It leads scientific research to improve minority health and eliminate health disparities by conducting and supporting research; planning, reviewing, coordinating, and evaluating all minority health and health disparities research at NIH; promoting and supporting the training of a diverse research workforce; translating and disseminating research information; and fostering collaborations and partnerships. For more information about NIMHD, visit http://www.nimhd.nih.gov.
About the National Institutes of Health (NIH):
NIH, the nation’s major medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
About the Ola HAWAIʻI grant:
Funded by the National Institute on Minority Health and Health Disparities, National Institutes of Health, Ola HAWAIʻI has been awarded for 5 years (September 2017 – June 2022), grant #2U54MD007601-31 for a total amount of $23,105,067.